Charles Krauthammer:

But I think the more general issue about the politics of this is I think Pelosi has led her party over a cliff on this. If, as is less likely, it gets stuck in the Senate and a lot of Democrats are way out on a limb the way they were after the big cap and trade vote in the House, if it passes in a form in the Senate, the Democrats are going to have a healthcare proposal which I think will haunt them for a decade.
There is so much pain in here - increase in taxes, increase in premiums, extra bureaucracy, interference in the medical treatment of patients - which people will be able to feel and to see within months and surely within years. This will be a millstone around Democrats for years if it passes.